The SQUIRT microplate washer's unique slit manifold design minimizes maintenance associated with clogged probes and the ‘donut effect’ where cells are removed during aspiration with traditional probe based instruments. A plate inversion/underside spraying technique achieves a wash efficiency of greater than 106. SQUIRT microplate washers are the perfect addition for any lab performing cell based assays, ELISAs, coating microplates, or conducting high content screening or proteomics and genomics research.